Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis

Klein, Paul A. and Jacobson, Elliott (2001) Further strategies for evaluating the etiological role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis. Gainesville, FL, Florida Cooperative Fish and Wildlife Research Unit , University of Florida,

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Abstract

In 1992, an interdisciplinary research team headquartered at the University of Florida began studies in key targeted areas of fibropapillomatosis (FP) etiology and pathogenesis. At that time, little was known about FP outside of field studies documenting its prevalence in different areas of the world and studies of tumor histopathology. Our primary objective was to develop a broad-based scientific understanding of FP by applying principles of tumor biology, immunology, pathology, virology, molecular biology, and epidemiology to FP in the green turtle, Chelonia mydas. Long-term goals included the development of assays for FP and study of any role of environmental co-factors in the disease. This report is a continuation of that effort and the results reported here bring us closer to understanding the role of a tumor-associated herpesvirus in marine turtle fibropapillomatosis. This research has demonstrated that marine turtle herpesviruses can persist for extended periods of time as infectious agents in the marine environment and that wild green turtles in Florida are exposed to the LETD-associated herpesvirus. This is the first description of LETV infection in free-ranging. marine turtles. In addition, data is presented that supports the hypothesis that LETV and FPHV infections are independent. These data reveal new levels of complexity that must be addressed before reliable serodiagnostic assays for herpesvirus infections of chelonians can be developed for widespread application. The results reported here also raise new concerns about the potential impact of infections by new herpesviruses on populations of wild marine turtles, an area which has previously been unexplored by turtle biologists. (8 page document)

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