Pathogenic, Molecular, and Immunological Properties of a Virus Associated with Sea Turtle Fibropapillomatosis. Phase II : Viral Pathogenesis and Development of Diagnostic Assays

Klein, Paul A. and Ehrhart, Llewellyn and Brown, Daniel R. and Bjorndal, Karen A. and Coberley, Sadie and Bolten, Alan and Moretti, Ritchie H. and Herbst, Lawrence H. and Lackovich, Joel K. (2000) Pathogenic, Molecular, and Immunological Properties of a Virus Associated with Sea Turtle Fibropapillomatosis. Phase II : Viral Pathogenesis and Development of Diagnostic Assays. Gainesville, FL, Florida Cooperative Fish and Wildlife Research Unit , University of Florida,

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Abstract

Research conducted under this RWO from July 1, 1997 through June 30, 2000 has provided important new information about the pathogenesis, virology, and immunology of marine turtle fibropapillomatosis. In particular, we have provided strong evidence for the association of a herpesvirus with fibropapillomatosis of the green turtle,Chelonia mydas, and the loggerhead turtle, Caretta caretta, in Florida. In addition we have provided new evidence for the absence of papillomaviruses from sea turtle fibropapillomas. Although unsuccessful, important new attempts were made to cultivate the FP-associated herpesvirus in vitro in collaboration with the National Wildlife Health Center. During this period of time, we completed publication of the first comprehensive description of the comparative pathology and pathogenesis of experimentally induced and spontaneous fibropapillomas of green turtles (Chelonia mydas). We initiated innovative studies on the persistence of a Chelonian herpesviruses in the marine environment demonstrating for the first time that the environmental survivability of Chelonian herpesviruses makes them real threats to marine turtle health. Finally, we explored development of a serological assay for FP using synthetic herpesvirus peptides and developed methodologies for detection of antibodies to LETV [Iung-eye-trachea virus] a disease-associated herpesvirus of the green turtle, Chelonia mydas.. This last initiative is ongoing and will further our efforts to develop specific immunological assays for the FP-associated herpesvirus and FP. (17 page document)

Item Type: Monograph or Serial Issue
Title: Pathogenic, Molecular, and Immunological Properties of a Virus Associated with Sea Turtle Fibropapillomatosis. Phase II : Viral Pathogenesis and Development of Diagnostic Assays
Personal Creator/Author:
CreatorsEmail
Klein, Paul A.
Ehrhart, Llewellyn
Brown, Daniel R.
Bjorndal, Karen A.
Coberley, Sadie
Bolten, Alan
Moretti, Ritchie H.
Herbst, Lawrence H.
Lackovich, Joel K.
Date: 2000
Publisher: Florida Cooperative Fish and Wildlife Research Unit , University of Florida
Place of Publication: Gainesville, FL
Projects: Research Work Order no. 180
Issuing Agency: Florida Cooperative Fish and Wildlife Research Unit
Uncontrolled Keywords: Green turtle; Chelonia mydas; fibropapillomatosis; diseases; Florida; Loggerhead turle; Caretta caretta; marine turtles, diagnostic assays
Subjects: Health
Biology
Item ID: 1093
Depositing User: Stephanie Haas
Date Deposited: 06 May 2008 20:45
Last Modified: 29 Sep 2011 21:09
URI: http://aquaticcommons.org/id/eprint/1093

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