Potential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding process

Hurton, Lenka and Berkson, Jim (2006) Potential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding process. Fishery Bulletin, 104(2), pp. 293-298.

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Abstract

Biomedical companies catch and bleed horseshoe crabs for the production of Limulus amebocyte lysate (LAL), a product used for protecting public health (Berkson and Shuster, 1999). LAL is a clotting agent, derived solely from horseshoe crab blood cells, which is used to detect the presence of pathogenic gramnegative bacteria in injectable drugs and implantable medical and dental devices (Mikkelsen, 1988; Novitsky, 1991). In addition, LAL is used in many diagnostic tests for such illnesses as gram-negative bacterial meningitis and typhoid fever (Ding and Ho, 2001). Because the LAL test allows one to detect femtogram levels of endotoxin (Ding and Ho, 2001), it is the most effective test for detecting endotoxin contamination, and its increasing use in medical and pharmaceutical laboratories makes it a highly valued product.

Item Type: Article
Title: Potential causes of mortality for horseshoe crabs (Limulus polyphemus) during the biomedical bleeding process
Personal Creator/Author:
CreatorsEmail
Hurton, Lenka
Berkson, Jim
Refereed: Yes
Journal or Publication Title: Fishery Bulletin
Volume: 104
Number: 2
Page Range: pp. 293-298
Date: 2006
ISSN: 0090-0656
Issuing Agency: United States National Marine Fisheries Service
Subjects: Biology
Ecology
Fisheries
Item ID: 8997
Depositing User: Patti M. Marraro
Date Deposited: 03 Aug 2012 18:18
Last Modified: 03 Aug 2012 18:18
URI: http://aquaticcommons.org/id/eprint/8997

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